{"id":1552,"date":"2015-06-18T16:42:05","date_gmt":"2015-06-18T16:42:05","guid":{"rendered":"https:\/\/pgdf.org\/?p=1552"},"modified":"2015-09-16T21:21:50","modified_gmt":"2015-09-16T21:21:50","slug":"study-identifies-hormone-glp-1-as-possible-therapeutic-target-for-aud","status":"publish","type":"post","link":"https:\/\/pgdf.org\/study-identifies-hormone-glp-1-as-possible-therapeutic-target-for-aud\/","title":{"rendered":"Study identifies hormone GLP-1 as possible therapeutic target for AUD"},"content":{"rendered":"<p>An appetite-regulating hormone called GLP-1 has been identified by an NIH study as a possible therapeutic target in the treatment of alcohol use disorder (AUD). GLP-1 resides in the digestive system and is known to play a significant role in regulation of type 2 diabetes because of its ability to make the body more sensitive to insulin and to promote insulin production. Preliminary studies published in June\u2019s <em>Translational Psychiatry<\/em> seeking a connection between the digestive system, liver, and brain relative to AUD suggest that GLP-1 may also have an effect on alcohol craving.<\/p>\n<p>The translational paper, authored by Lorenzo Leggio, Chief of the joint NIAAA-NIDA Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, LCTS, and colleagues, includes five distinct queries:<\/p>\n<ul>\n<li>Is genetic variation in GLP-1 associated with AUD? This study was carried out using human subjects at the NIAAA intramural research program.<\/li>\n<li>Can this association be confirmed in an independent cohort? The independent cohort used was the <a href=\"https:\/\/ega.crg.eu\/studies\/phs000092.v1.p1\" target=\"_blank\" data-ga-trigger=\"click\" data-ga-category=\"Text Link\" data-ga-action=\"Study identifies hormone GLP-1 as possible therapeutic target for AUD\" data-ga-label=\"SAGE study\">SAGE study<\/a>.<\/li>\n<li>In post-hoc analysis, what are the effects of GLP-1 risk alleles on intravenous alcohol self-administration?<\/li>\n<li>Analysis of fMRI scans of brain activity during reward cues. The scans were acquired from human subjects enrolled for alcohol treatment at NIH.<\/li>\n<li>What is the effect of GLP-1 receptor agonism (stimulation) on alcohol consumption in a mouse model of study?<\/li>\n<\/ul>\n<p>These studies provided sufficient evidence to associate GLP-1 genetic variation with AUD. Additionally, the fifth study using a mouse model showed significantly reduced alcohol consumption in subjects who received medication that activated the GLP-1 receptor. These preliminary studies set the stage for a larger study exploring the GLP-1 receptor as a therapeutic target in humans with AUD.<\/p>\n<p>The study\u2019s authors state, \u201cGLP-1 analogues are already approved and clinically used for the treatment of type 2 diabetes. Our study suggests the [GLP-1 receptor] as a candidate treatment target, potentially with a particular utility in a genetically identified subpopulation of AUD patients.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An appetite-regulating hormone called GLP-1 has been identified by an NIH study as a possible therapeutic target in the treatment of alcohol use disorder (AUD). GLP-1 resides in the digestive system and is known to play a significant role in &hellip; <a href=\"https:\/\/pgdf.org\/study-identifies-hormone-glp-1-as-possible-therapeutic-target-for-aud\/\">Continued<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[17],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/posts\/1552"}],"collection":[{"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/comments?post=1552"}],"version-history":[{"count":4,"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/posts\/1552\/revisions"}],"predecessor-version":[{"id":1645,"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/posts\/1552\/revisions\/1645"}],"wp:attachment":[{"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/media?parent=1552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/categories?post=1552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pgdf.org\/wp-json\/wp\/v2\/tags?post=1552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}